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CD光谱仪,圆二色(CD)光谱仪,圆二色Chirascan,Circular Dichroism Spectrometer,英国应用光物理,应用光物理公司,Applied Photophysics,英国 Chirascan , Chirascan-plus,Chirascan V100 , Chirascan Q100...
产品分类 PRODCT
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案例分析高通量DSF方法快速筛选曲妥珠单抗的制剂配方 生物**抗体的配方是确保稳定**产品的生产、储存和运输的基础。配方的开发过程,需要采用高通量方法来可靠、快速地筛选大量配方条件,以确定*佳的制剂和*好的条件。一种广泛使用的方法是做热变性测试和推导相关参数,如Tm和Tonset,以对配方条件和辅料的稳定效果进行分级筛选。传统的无标记热变性技术受到通量上的限制,比如样品浓度、体积、耗材成本和测量速度等等,这使有成百上千种潜在条件的配方筛选过程成为一个发布时间:2024-02-03 23:35 点击次数:22 次
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高通量DSF快速分析热稳定性Tm方法在单抗 NISTab中的应用及与DSC方法的比较分析 NISTmAb是一种广泛表征的单克隆抗体,旨在用作开发**蛋白表征新技术中的标样。在本应用文献中,我们使用SUPR-DSF来获取NISTmAb的差示扫描荧光法(DSF)的数据,并将结果与差示扫描量热法(DSC)进行比较。SUPR-DSF解析了NISTmAb所有的三个结构域:CH2(69oC),CH3(83oC)和高解链温度的FAB结构域(94oC)[1]。此外,所测得的Tm值与文献的报道完全一致。发布时间:2024-02-03 23:19 点击次数:25 次
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Targeting Optimal Buffers for Downstream Crystallisation Screening Elucidationofproteinstructureisrequiredtofullyunderstandproteinmechanismsofactionand function.Structuralstudiesinitiallyrequirepurificationofrecombinantproteinsthatare subsequentlyusedfordownstreamexp发布时间:2023-10-15 22:09 点击次数:57 次
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Using High Throughput Differential Scanning Fluorimetry to Obtain Binding Parameters Bindinganalysisstudiesareacrucialareaofdrugdevelopment.Thecharacterisationofinteraction andtheKD(Dissociationconstant)parameterarecriticalinselectingsuitablecandidatesfor development.Poordataquality,f发布时间:2023-10-15 22:02 点击次数:56 次
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Speeding Up Early Stage Biotherapeutic Discovery with Next Generation Differential Scanning Fluorime Limitedamountsofsampleoftenhindertheanalysesneededfortheselectionandoptimizationofthecandidatesintheearlystagesofbiotherapeuticdiscovery.Examplesofanalysesareactivity(oftenbindingthetargetandcausingac发布时间:2023-10-15 21:48 点击次数:64 次
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Finding Formulations Faster with SUPR-DSF UsingtheSUPR-DSFwithapre-madeformulationplateaddressesbothofthoseissues.TheSUPR-DSFcanreliablymeasurethermaldenaturationcurvesviaintrinsicfluorescenceincommerciallyavailable384-wellmicroplates.Thisal发布时间:2023-10-15 21:33 点击次数:58 次
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Differential Scanning Fluorimetry Reaches New Peaks on the NISTmAb TheNISTmAbisawidelycharacterisedmonoclonalantibodyintendedtobeusedasareferencemoleculeinthedevelopmentofnoveltechnologyfortherapeuticproteincharacterisation.Inthisapplicationnote,weusetheSUPR-DSFtoacq发布时间:2023-10-15 21:30 点击次数:48 次
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Formulation screen of Trastuzumab using the SUPR-DSF Inthisreportweshowtheanalysisofathermaldenaturation-basedformulationscreenofthecommerciallyavailabletherapeuticantibodyTrastuzumab,in96differentconditionswiththeSUPR-DSFinstrument.Alongwithscreeningth发布时间:2023-10-14 21:41 点击次数:50 次